Table 4.
Association of H. pylori and its virulence genes vacA s1m1, cagA, babA2 with gastric ulcer and gastric cancer
| Diagnosis | ||||
|---|---|---|---|---|
| Gastric ulcer | Gastric cancer | |||
| OR (CI 95%) | p value | ORa (CI 95%) | p value | |
| H. pylori | ||||
| Negative | 1.0b | 1.0b | ||
| Positive | 1.07 (0.71–1.61) | 0.728 | 2.08 (1.05–4.13) | 0.035 |
| vacA | ||||
| s2m2 | 1.0b | 1.0b | ||
| s1m1 | 2.02 (1.12–3.62) | 0.019 | 6.58 (2.15–20.08) | 0.001 |
| cagA | ||||
| Negative | 1.0b | 1.0b | ||
| Positive | 1.02 (0.56–1.86) | 0.934 | 1.22 (0.47–3.17) | 0.676 |
| babA2 | ||||
| Negative | 1.0b | 1.0b | ||
| Positive | 0.97 (0.50–1.85) | 0.927 | 2.50 (0.99–6.32) | 0.052 |
| Genotype | ||||
| s2m2/cagA− | 1.0b | 1.0b | ||
| s2m2/cagA+ | 2.5 (0.33–18.6) | 0.374 | – | – |
| s1m1/cagA− | 4.3 (1.02–18.2) | 0.047 | 1.8 (0.15–22.1) | 0.639 |
| s1m1/cagA+ | 1.5 (0.40–5.5) | 0.550 | 2.1 (0.25–16.8) | 0.502 |
aOR adjusted for age and overcrowding
bReference group: chronic gastritis