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. 2017 Apr 13;18:299. doi: 10.1186/s12864-017-3640-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Klf9 target genes are dysregulated in Klf9 HT22 depleted cells and in Klf9 knockout mice, and depletion of Klf9 accelerates the cell cycle in HT22 cells. a Klf9 target genes are dysregulated in HT22 cells with Klf9 depleted by CRISPR/Cas9 genome editing. Asterisks indicate a statistically significant difference from the parent HT22 cell line (p < 0.05; ANOVA followed by Holm-Sidak post-hoc test). b Klf9 target genes are dysregulated in the hippocampus of postnatal day 7 Klf9-null mice. Asterisks indicate a statistically significant difference from wild-type mice by Student’s two-sample t-test (p < .05). c Cells with Klf9 depleted by CRISPR/Cas9 genome editing showed a higher percentage of cells in M phase (gray bars, lowercase letters) and a lower percentage in G1/G0 phase (black bars, uppercase letters). Means with the same letter are not significantly different (p < .05; ANOVA followed by Holm-Sidak post-hoc test). d The mRNA levels for two Klf9 target genes involved with cell cycle control are increased in Klf9 mutant HT22 cells. Means with the same letter are not significantly different (p < .05; ANOVA followed by Holm-Sidak post-hoc test)