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. 2017 Jan 24;27(2):903–918. doi: 10.1093/cercor/bhx003

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Intrahippocampal heparinase 1 injection impairs context discrimination in CFC. (a) Experimental design of CFC with injection of either active heparinase (heparinase) or heat-inactivated heparinase (control) 24 h before CFC. (b) The group of mice injected with heparinase showed normal level of freezing in a neutral context (CC−) before CFC on d0, and in the conditioned context (CC+) after CFC on d1 and d3. However, they were unable to discriminate the conditioned context (CC+, solid bars) from the unconditioned, neutral one (CC−, empty bars). (c) The discrimination ratio (%) of freezing in the 2 different contexts (at the left panel) after control/heparinase injection confirms the inability of mice to discriminate 2 different but similar contexts after HSs were removed by heparinase injection into the dorsal hippocampus.