Table 1.
Comparisons between the patients’ demographics, phenotypic and genotypic characteristics of HA-MRSA and CA-MRSA in 2011 and 2012
| 2011 | 2012 | P value | Total | P value | |
|---|---|---|---|---|---|
| N = 95 (%) | N = 114 (%) | N = 209 (%) | |||
| Age | |||||
| ≤ 50 years old | 39 (41.1) | 27 (23.7) | 0.011 | 66 (31.6) | < 0.0001 |
| > 50 years old | 52 (54.7) | 86 (75.4) | 0.002 | 138 (66) | |
| Not Known | 4 (4.2) | 1 (0.9) | 5 (2.4) | ||
| Gender | |||||
| Female | 30 (31.6) | 44 (38.6) | 0.312 | 74 (35.4) | < 0.0001 |
| Male | 62 (65.3) | 70 (61.4) | 0.666 | 132 (63.2) | |
| Not Known | 3 (3.2) | 0 (0) | 3 (1.4) | ||
| Source | |||||
| Blood | 40 (42.1) | 51 (44.7) | 0.780 | 91 (43.5) | |
| Tissue | 37 (38.9) | 42 (36.8) | 0.776 | 79 (37.8) | |
| CSF | 3 (3.2) | 0 (0) | 0.092 | 3 (1.4) | |
| Pus, slough & Abscess | 8 (8.4) | 11 (9.6) | 0.813 | 19 (9.1) | |
| Pericardial fluid | 1 (1.1) | 0 (0) | 0.455 | 1 (0.5) | |
| Bullae fluid | 0 (0) | 1 (0.9) | 1.000 | 1 (0.5) | |
| Synovial fluid | 2 (2.1) | 2 (1.8) | 1.000 | 4 (1.9) | |
| Bone | 4 (4.2) | 7 (6.1) | 0.758 | 11 (5.3) | |
| SCCmec types | |||||
| SCCmec I | 0 (0) | 0 (0) | 0 (0) | ||
| SCCmec II | 2 (2.1) | 0 (0) | 0.205 | 2 (0.9) | |
| SCCmec III | 61 (64.2) | 78 (68.4) | 0.558 | 139 (66.5) | |
| SCCmec IV | |||||
| SCCmec IVa | 5 (5.3) | 4 (3.5) | 0.735 | 9 (4.3) | |
| SCCmec IVb | 5 (5.3) | 0 (0) | 0.018 | 5 (2.4) | |
| SCCmec IVc | 0 (0) | 0 (0) | 0 (0) | ||
| SCCmec IVd | 0 (0) | 0 (0) | 0 (0) | ||
| Novel subtypes | 15 (15.8) | 30 (26.3) | 0.090 | 45 (21.5) | |
| SCCmec V | 6 (6.3) | 1 (0.9) | 0.048 | 7 (3.3) | |
| Untypeable | 1 (1.1) | 1 (0.9) | 1.000 | 2 (0.9) | |
| Type of MRSA | |||||
| HA-MRSA | 44 (46.3) | 79 (69.3) | 0.001 | 123 (58.9) | |
| SCCmec II | 2 (4.5) | 0 (0) | 0.126 | 2 (1.6) | |
| SCCmec III | 35 (79.5) | 56 (70.9) | 0.392 | 91 (73.9) | |
| SCCmec IV | |||||
| SCCmec IVa | 1 (2.3) | 3 (3.8) | 1.000 | 4 (3.3) | |
| SCCmec IVb | 3 (6.8) | 0 (0) | 0.044 | 3 (2.4) | |
| Novel subtypes | 3 (6.8) | 19 (24.1) | 0.025 | 22 (17.9) | |
| SCCmec V | 0 (0) | 1 (1.3) | 1.000 | 1 (0.8) | |
| CA-MRSA | 41 (43.2) | 24 (21.1) | 0.001 | 65 (31.1) | |
| SCCmec III | 23 (56.1) | 13 (54.2) | 1.000 | 36 (55.4) | |
| SCCmec IV | |||||
| SCCmec IVa | 4 (9.8) | 1 (4.2) | 0.644 | 5 (7.7) | |
| SCCmec IVb | 2 (4.9) | 0 (0) | 0.527 | 2 (3.1) | |
| Novel subtypes | 7 (17.1) | 10 (41.7) | 0.042 | 17 (26.2) | |
| SCCmec V | 4 (9.8) | 0 (0) | 0.288 | 4 (6.2) | |
| Untypeable | 1 (2.4) | 0 (0) | 1.000 | 1 (1.5) | |
| Not Known | 10 (10.5) | 11 (9.6) | 21 (10) | ||
| SCCmec III | 3 (30) | 9 (81.8) | 12 (57.1) | ||
| SCCmec IV | |||||
| Novel subtypes | 5 (50) | 1 (9.1) | 6 (28.6) | ||
| SCCmec V | 2 (20) | 0 (0) | 2 (9.5) | ||
| Untypeable | 0 (0) | 1 (9.1) | 1 (4.8) | ||
| PVL gene | 5 (5.3) | 0 (0) | 0.018 | 5 (2.4) | |
| Vancomycin MIC | |||||
| < 1.5 μg/mL | 58 (61.1) | 48 (42.1) | 0.008 | 106 (50.7) | |
| ≥ 1.5 μg/mL | 37 (38.9) | 66 (57.9) | 103 (49.3) | ||
CSF Cerebrospinal fluid
Fisher’s exact test done for categorical variables, p value < 0.05 was considered to be statistical significant and are indicated by bold text