Table 1.
Gene Symbol | Thermoneutral | Heat Stress | Gene Function | ||||
---|---|---|---|---|---|---|---|
P-value | Log2FC | FDR | P-value | Log2FC | FDR | ||
STMN1 | 5.30E-05 | 1.24 | 0.023 | 0.0003 | −1.59 | 0.066 | Regulates microtubule dynamics in cell division [105] |
CDC45 | 5.11E-05 | 1.34 | 0.023 | 0.00046 | −1.71 | 0.076 | Key replication helicase cofactor in DNA replication [70] |
DNA2 | 7.47E-06 | 1.71 | 0.0078 | 5.99E-05 | −2.31 | 0.030 | Essential DNA-helicase for chromosome replication [106] |
CCNB2 | 0.00025 | 1.17 | 0.065 | 0.00042 | −1.63 | 0.075 | Important regulator required for cell mitosis [107] |
dAK | 0.00028 | 1.46 | 0.070 | 1.88E-08 | −3.33 | 0.00011 | Crucial regulator for DNA precursor synthesis [108] |
MKLP1 | 6.14E-05 | 1.10 | 0.025 | 0.00046 | −1.40 | 0.076 | Mediates cell cycle cytokinesis [109] |
CDC20 | 2.28E-06 | 1.58 | 0.0032 | 0.00029 | −1.74 | 0.065 | Regulates chromosome segregation and mitotic exit [110] |
SMC2 | 0.00023 | 1.32 | 0.064 | 2.81E-06 | −2.44 | 0.0042 | Essential for chromosome segregation and condensation [111] |
FXYD2 | 1.08E-08 | −2.03 | 6.08E-05 | 3.36E-09 | 3.00 | 3.79E-05 | Required for ion transport in heart [112] |
SNTB1 | 7.48E-06 | −1.09 | 0.0078 | 6.21E-05 | 1.41 | 0.030 | Involved in muscle contraction [113] |
KIAA1210 | 0.00017 | −1.26 | 0.052 | 0.00011 | 1.87 | 0.046 | Unknown |
AVD | 2.15E-06 | −3.55 | 0.0032 | 2.05E-05 | 4.43 | 0.016 | Unknown |
AGTR1 | 0.00012 | −3.51 | 0.041 | 2.95E-06 | 6.00 | 0.0042 | Important role in pathogenesis of cardiac hypertrophy [85] |
PERP | 0.00012 | −1.05 | 0.040 | 7.78E-06 | 1.78 | 0.0098 | Mediates p53-dependent apoptosis [114] |
Log 2 FC: log2 fold change, FDR: False Discovery Rate