Table 1.
Differential gene expression: largest effect sizes
| Gene | M/Y | Y Mean | M Mean | Annotation |
|---|---|---|---|---|
| Abp10 | 0.46 | 677 | 311 | Annexin V-binding protein |
| Aff4 | 0.45 | 458 | 204 | Transcription factor and central SEC component |
| Ago2 | 0.43 | 330 | 141 | RISC Catalytic Component 2 |
| Aqp4 | 0.50 | 2664 | 1329 | Aquaporin family member |
| Arl11 | 2.07 | 94 | 195 | ADP-ribosylation factor-like 11 |
| Asap1 | 0.40 | 524 | 212 | ADP-ribosylation factor (ARF) GTPase-activating protein |
| Bmpr2 | 0.46 | 970 | 449 | Bone morphogenetic protein receptor type II |
| C3 | 2.40 | 830 | 1996 | Central complement component |
| Chrdl1 | 2.48 | 60 | 148 | Ventroptin, antagonizes BMP actions |
| Clec12a | 2.18 | 99 | 215 | CTL/CTLD member, widely expressed in innate immune system |
| Cspp1 | 0.49 | 207 | 101 | Important for normal neural specific cilia function |
| Dnajb12 | 6.70 | 52 | 350 | DNAJ/HSP40 family member, regulates molecular chaperone activity, protein folding and degradation |
| Enc1 | 0.47 | 135 | 64 | Kelch-related family of actin-binding proteins, role in oxidative stress response, regulates Nrf2 |
| Falz | 0.50 | 482 | 239 | Transcription/epigenetic regulator, up-modulated in neurodegenerative diseases |
| Fcgr2b | 2.89 | 303 | 878 | Low affinity Fc receptor expressed in microglia |
| Fcrls | 2.78 | 218 | 607 | Fc receptor; part of TGFb1 microglial signature response |
| Fmo2 | 2.35 | 87 | 204 | Flavin-containing monooxygenase |
| Fstl3 | 2.13 | 66 | 142 | Secreted form binds/antagonizes members of TGF-b family, e.g., BMP2 |
| Gipr | 3.49 | 179 | 623 | Receptor for neuroprotective polypeptide GIP |
| Golga4 | 0.42 | 211 | 89 | Role in Rab6-regulated membrane-tethering events in the Golgi |
| Gpnmb | 3.14 | 420 | 1317 | Expressed in microglia, inflammatory response gene |
| Herc1 | 0.36 | 294 | 107 | Regulator of membrane trafficking |
| Kif1a | 0.38 | 3058 | 1160 | Kinesin family protein involved in syaptogenesis |
| Lgals3 | 2.44 | 927 | 2264 | Member galectin family of carbohydrate binding proteins; microglial marker and alt priming gene |
| Msi2 | 0.49 | 304 | 148 | RNA binding protein; role in CNS stem cell proliferation |
| Nrg1 | 0.46 | 553 | 253 | Neuregulin-1, signals through erb2/3 receptors, functions in neural development and plasticity |
| Pitpnm1 | 3.50 | 499 | 1749 | Transfers PtdIns from ER to plasma membrane |
| Postn | 2.73 | 147 | 402 | Aka periostin; enhances TGF-β signaling, facilitates BMP1, expressed in reactive microglia and astrocytes, neuroprotective |
| Pou3f1 | 2.16 | 266 | 574 | Transcription factor, promotes stem cell commitment to neural fate |
| RT1-EC2 | 2.50 | 75 | 189 | Class I MHC, up-modulated in spinal cord injury and neurodegeneration |
| S100a8 | 2.30 | 85 | 194 | Induced in macrophages and dendritic cells by TLR agonists, oxidative stress and corticosterone |
| Slc9a3 | 2.15 | 195 | 421 | Sodium/proton exchanger; Cation Proton Antiporter 3 |
| Tnc | 2.32 | 75 | 173 | Extracellular matrix protein, up regulated following CNS trauma |
| Unc5b | 0.47 | 995 | 469 | Netrin receptor family; required for axon guidance; maintains blood–brain barrier |
| Usp7 | 0.46 | 121 | 56 | Uiquitin-specific-processing protease 7, deubiquitinates range Deubiquitinates target proteins |
The annotated differential gene set (353) was filtered for largest effect sizes. Mean probe set expression levels (arbitrary units) for Y (young) and M (middle age) genes are shown