Table 2.
Clinical characteristics of SOF participants by CKD-EPIcr,cysc eGFR category.
| Baseline characteristics | Overall (N = 1289) |
CKD-EPIcr,cysc eGFR category (mL/min/1.73 m2) | p value | |||
|---|---|---|---|---|---|---|
| ≥75 | 60 to 74 | 45–59 | <45 | |||
| (N = 432) | (N = 430) | (N = 284) | (N = 143) | |||
| Age, years, mean (SD) | 79.5 (4.6) | 77.7 (4.1) | 79.4 (4.2) | 81.3 (4.8) | 82.0 (4.8) | <0.001 |
| Race/ethnicity, n (%) | <0.001 | |||||
| White | 1159 (89.9) | 355 (82.2) | 399 (92.8) | 270 (95.1) | 135 (94.4) | |
| Black | 130 (10.1) | 77 (17.8) | 31 (7.2) | 14 (4.9) | 8 (5.6) | |
| Education, n (%) | 0.031 | |||||
| Less than high school | 229 (17.8) | 62 (14.4) | 69 (16.1) | 65 (23.0) | 33 (23.1) | |
| High school | 538 (41.8) | 190 (44.1) | 182 (42.4) | 116 (41.0) | 50 (35.0) | |
| College/grad school | 519 (40.4) | 179 (41.5) | 178 (41.5) | 102 (36.0) | 60 (42.0) | |
| Body mass index, kg/m2, mean (SD) | 26.8 (5.0) | 26.1 (4.9) | 27.1 (5.0) | 27.0 (4.8) | 27.4 (5.2) | 0.008 |
| Current smoker, n (%) | 58 (4.5) | 27 (6.3) | 15 (3.5) | 12 (4.2) | 4 (2.8) | 0.167 |
| Self-rated health good/excellent, n (%) | 1035 (80.4) | 366 (84.7) | 357 (83.0) | 217 (76.4) | 95 (66.9) | <0.001 |
| Hypertension∗, n (%) | 795 (61.7) | 235 (54.4) | 242 (56.3) | 196 (69.0) | 122 (85.3) | <0.001 |
| Diabetes mellitus∗, n (%) | 95 (7.4) | 33 (7.6) | 23 (5.4) | 23 (8.1) | 16 (11.3) | 0.112 |
| Self-reported stroke, n (%) | 60 (4.7) | 18 (4.2) | 10 (2.3) | 20 (7.0) | 12 (8.5) | 0.003 |
| Self-reported coronary heart disease†, n (%) | 246 (19.1) | 73 (16.9) | 67 (15.6) | 62 (21.8) | 44 (31.0) | <0.001 |
| Self-reported congestive heart failure, n (%) | 65 (5.1) | 21 (4.9) | 12 (2.8) | 20 (7.0) | 12 (8.5) | 0.016 |
| CKD-EPIcr,cysc eGFR, mean (SD) | 66.7 (16.7) | 84.6 (7.1) | 67.6 (4.2) | 53.5 (4.1) | 36.3 (7.2) | <0.001 |
| Follow-up time, years, mean (SD) | 9.2 (4.0) | 10.2 (3.8) | 9.6 (3.9) | 8.3 (4.0) | 6.8 (4.1) | <0.001 |
eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin C.
∗As determined by self-report or any disease-specific medication use.
†Coronary heart disease includes myocardial infarction, angina, and other heart diseases.