Table 4.
Association of eGFR category and cardiovascular mortality.
| Estimating equation category, mL/min/1.73 m2 | Age adjusted incidence rate per 1,000 person years (95% CI) | Hazard ratio (95% confidence interval) | |||
|---|---|---|---|---|---|
| Unadjusted (site only) | Base model∗ | MV model† | Final model‡ | ||
| BIS1 | |||||
| ≥75 | 45.7 (0.8, 90.6) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 60 to <75 | 16.5 (11.7, 21.3) | 0.8 (0.5, 1.2) | 0.7 (0.4, 1.1) | 0.8 (0.5, 1.2) | 0.8 (0.5, 1.2) |
| 45 to <60 | 18.7 (14.6, 22.8) | 1.3 (0.8, 2.0) | 0.9 (0.6, 1.3) | 0.9 (0.6, 1.4) | 0.9 (0.6, 1.3) |
| <45 | 38.4 (22.9, 53.9) | 3.4 (2.2, 5.5) | 1.8 (1.1, 2.9) | 1.6 (0.9, 2.6) | 1.4 (0.9, 2.4) |
| p-trend | <0.001 | 0.005 | 0.036 | 0.099 | |
| CKD-EPIcr | |||||
| ≥75 | 19.1 (14.7, 23.4) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 60 to <75 | 19.1 (14.4, 23.8) | 1.4 (1.1, 2.0) | 1.1 (0.8, 1.6) | 1.1 (0.8, 1.5) | 1.0 (0.7, 1.4) |
| 45 to <60 | 20.3 (13.0, 27.6) | 1.6 (1.1, 2.4) | 1.2 (0.8, 1.7) | 1.0 (0.7, 1.5) | 1.0 (0.7, 1.5) |
| <45 | 39.7 (21.9, 57.5) | 4.1 (2.7, 6.1) | 2.6 (1.7, 4.0) | 2.1 (1.3, 3.2) | 1.8 (1.2, 2.8) |
| p-trend | <0.001 | <0.001 | 0.016 | 0.043 | |
| BIS2 | |||||
| ≥75 | 19.4 (9.6, 29.2) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 60 to <75 | 16.4 (12.1, 20.8) | 0.9 (0.5, 1.5) | 0.8 (0.5, 1.4) | 0.9 (0.5, 1.5) | 0.8 (0.5, 1.4) |
| 45 to <60 | 19.8 (15.6, 23.9) | 1.6 (0.9, 2.6) | 1.1 (0.7, 1.8) | 1.1 (0.7, 1.9) | 1.1 (0.6, 1.8) |
| <45 | 37.5 (25.5, 49.6) | 3.7 (2.2, 6.3) | 2.2 (1.3, 3.8) | 1.9 (1.1, 3.4) | 1.7 (0.9, 3.0) |
| p-trend | <0.001 | <0.001 | 0.001 | 0.006 | |
| CKD-EPIcr,cysc | |||||
| ≥75 | 17.5 (12.4, 22.6) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 60 to <75 | 17.8 (13.6, 21.9) | 1.3 (0.9, 1.9) | 1.1 (0.8, 1.6) | 1.1 (0.8, 1.6) | 1.1 (0.8, 1.6) |
| 45 to <60 | 21.5 (15.8, 27.3) | 2.2 (1.5, 3.2) | 1.5 (1.0, 2.2) | 1.4 (0.9, 2.0) | 1.3 (0.9, 1.9) |
| <45 | 48.3 (21.4, 75.2) | 3.9 (2.6, 5.9) | 2.5 (1.7, 3.8) | 2.0 (1.3, 3.1) | 1.8 (1.2, 2.8) |
| p-trend | <0.001 | <0.001 | 0.002 | 0.011 | |
eGFR, estimated glomerular filtration rate; BIS, Berlin Initiative Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin C.
∗Adjusted for age, race, and body mass index.
†Adjusted for age, race, body mass index, hypertension, and diabetes mellitus.
‡Adjusted for age, race, body mass index, hypertension, diabetes mellitus, history of CHD, and self-reported health status.