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Proposed mechanism by which P. cicadae abolished UVB-stimulated inflammation. Cartoon shows that P. cicadae decreases expression of MMPs, TM, and IL-6 in HaCaT cells. The suppressive effect of P. cicadae on photodamage was induced through JNK and p38 activation. P. cicadae suppression of the JNK or p38 pathway could diminish the UVB-induced AP-1, p53, and p65 activation. Moreover, P. cicadae-induced Nrf-2 activation and translocation from the cytosol to the nucleus.
