Table 4. Diagnostic Performance of Different Imaging Modalities for Coronary Artery Disease in Patients without Coronary Stent.

	CCTA	DE-CTP	SPECT	CCTA + DE-CTP	CCTA + SPECT
Per-vascular territory analysis
Sensitivity	100 (92–100) (20/20)	100 (92–100) (20/20)	70 (56–81) (14/20)	100 (92–100) (20/20)	70 (56–81) (14/20)
Specificity	84 (71–92) (21/25)	88 (75–95) (22/25)	96 (86–99) (24/25)	96 (86–99) (24/25)	100 (92–100) (25/25)
PPV	83 (70–92) (20/24)	87 (74–94) (20/23)	93 (82–98) (14/15)	95 (85–99) (20/21)	100 (92–100) (14/14)
NPV	100 (92–100) (21/21)	100 (92–100) (22/22)	80 (66–89) (24/30)	100 (92–100) (24/24)	81 (67–90) (25/31)
Accuracy	91 (79–97) (41/45)	93 (82–98) (42/45)	84 (71–92) (38/45)	98 (88–100) (44/45)	87 (74–94) (39/45)
AUC (95% CI)	0.92 (0.85–0.99)	0.94 (0.87–1.0)	0.83 (0.72–0.94)	0.98 (0.94–1.0)	0.85 (0.75–0.95)
Per-patient analysis
Sensitivity	100 (80–100) (12/12)	100 (80–100) (12/12)	83 (58–95) (10/12)	100 (80–100) (12/12)	83 (58–95) (10/12)
Specificity	33 (15–58) (1/3)	67 (42–85) (2/3)	100 (80–100) (3/3)	67 (42–85) (2/3)	100 (80–100) (3/3)
PPV	86 (61–96) (12/14)	92 (69–99) (12/13)	100 (80–100) (10/10)	92 (69–99) (12/13)	100 (80–100) (10/10)
NPV	100 (80–100) (1/1)	100 (80–100) (2/2)	60 (36–80) (3/5)	100 (80–100) (2/2)	60 (36–80) (3/5)
Accuracy	87 (62–96) (13/15)	93 (70–99) (14/15)	87 (62–96) (13/15)	93 (70–99) (14/15)	87 (62–96) (13/15)
AUC (95% CI)	0.67 (0.34–0.99)	0.83 (0.51–1.0)	0.92 (0.81–1.0)	0.83 (0.51–1.0)	0.92 (0.81–1.0)

Values of sensitivities, specificities, PPVs, NPVs, and accuracies are % (95% CI). AUC = area under the receiver operating characteristic curve, CCTA = coronary computed tomography angiography, CI = confidence interval, DE-CTP = dual-energy computed tomography perfusion, NPV = negative predictive value, PPV = positive predictive value, SPECT = single-photon emission computed tomography