Table 5. Diagnostic Performance of Different Imaging Modalities for Coronary Artery Disease in Patients with Coronary Stent.
| CCTA | DE-CTP | SPECT | CCTA + DE-CTP | CCTA + SPECT | |
|---|---|---|---|---|---|
| Per-vascular territory analysis | |||||
| Sensitivity | 88 (71–95) (7/8) |
88 (71–95) (7/8) |
63 (45–78) (5/8) |
75 (57–87) (6/8) |
63 (45–78) (5/8) |
| Specificity | 59 (42–75) (13/22) |
59 (42–75) (13/22) |
82 (65–92) (18/22) |
73 (55–85) (16/22) |
86 (70–95) (19/22) |
| PPV | 44 (28–61) (7/16) |
44 (28–61) (7/16) |
56 (38–72) (5/9) |
50 (33–67) (6/12) |
63 (45–78) (5/8) |
| NPV | 93 (78–98) (13/14) |
93 (78–98) (13/14) |
86 (69–94) (18/21) |
89 (73–96) (16/18) |
86 (70–95) (19/22) |
| Accuracy | 67 (49–81) (20/30) |
67 (49–81) (20/30) |
77 (59–88) (23/30) |
73 (56–86) (22/30) |
80 (63–91) (24/30) |
| AUC (95% CI) | 0.73 (0.57–0.89) | 0.73 (0.57–0.89) | 0.72 (0.52–0.92) | 0.74 (0.55–0.93) | 0.74 (0.55–0.94) |
| Per-patient analysis | |||||
| Sensitivity | 100 (6/6) |
100 (72–100) (6/6) |
100 (72–100) (6/6) |
100 (72–100) (6/6) |
83 (52–96) (5/6) |
| Specificity | 0 (0/4) |
25 (8–56) (1/4) |
25 (8–56) (1/4) |
25 (8–56) (1/4) |
25 (8–56) (1/4) |
| PPV | 60 (6/10) |
67 (37–87) (6/9) |
67 (37–87) (6/9) |
67 (37–87) (6/9) |
63 (33–85) (5/8) |
| NPV | – (0/0) |
100 (72–100) (1/1) |
100 (72–100) (1/1) |
100 (72–100) (1/1) |
50 (24–76) (1/2) |
| Accuracy | 60 (6/10) |
70 (40–89) (7/10) |
70 (40–89) (7/10) |
70 (40–89) (7/10) |
60 (31–83) (6/10) |
| AUC (95% CI) | – | 0.63 (0.38–0.87) | 0.63 (0.38–0.87) | 0.63 (0.38–0.87) | 0.54 (0.25–0.84) |
Values of sensitivities, specificities, PPVs, NPVs, and accuracies are % (95% CI). AUC = area under the receiver operating characteristic curve, CCTA = coronary computed tomography angiography, CI = confidence interval, DE-CTP = dual-energy computed tomography perfusion, NPV = negative predictive value, PPV = positive predictive value, SPECT = single-photon emission computed tomography