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. 2017 Feb 7;26(7):1268–1279. doi: 10.1093/hmg/ddx031

Figure 5.

Figure 5

Morphological analysis following conditional deletion of Rdh10 during craniofacial development. Nuclear fluorescent image of the maxillary complex in E11.5 control mouse embryos (A). Red arrowhead indicates the position of the primitive choana, which still forms in Wnt1Cre;Rdh10flox/flox (neural crest-specific deletion of Rdh10) mice (B). At E12.5, the nasal cavity invaginates posteriorly in control mice (C, red arrowhead), but is impaired and hypoplastic in E10.5 tamoxifen (TMX)-administered embryos (D, red arrowhead). (E) Schematic drawing of the phenotype of Cre-ERT2; Rdh10flox/flox embryos at E12.5 according to when the tamoxifen is administrated. TMX E10.5, administered tamoxifen at E10.5. MNP, medial nasal process. LNP, lateral nasal process. MXP, maxillary process.