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SDHD-G12S or SDHD-H50R suppressing autophagy is PTEN-dependent. Western blot showing PTEN knockdown in Nthy-Ori-3 (A) and TPC1 (B) thyroid cells with stable expression of SDHD-WT or SDHD variants G12S or H50R (left panels). Western blot reveals autophagy marker (LC3BII and p62) levels in (A) Nthy-Ori-3 and (B) TPC1 cells stably expressing SDHD-WT, SDHD-G12S or SDHD-H50R after PTEN knockdown (right panels). Blots shown are best representatives of three separate experiments.
