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. 2016 Oct 19;12(1):1–23. doi: 10.1093/scan/nsw154

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© The Author(s) (2016). Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 6. — A large-scale system for allostasis and interoception in the human brain. (A) The system implementing allostasis and interoception is composed of two large-scale intrinsic networks (shown in red and blue) that are interconnected by several hubs (shown in purple; for coordinates, see Kleckner et al., in press). Hubs belonging to the ‘rich club’ are labeled. These maps were constructed with resting state BOLD data from 280 participants, binarized at p < 10⁻⁵, and then replicated on a second sample of 270 participants. vaIns, ventral anterior insula; MCC, midcingulate cortex; PHG, parahippocampal gyrus; PostCG, postcentral gyrus; PAG, periaqueductal gray; PBN, parabrachial nucleus; NTS, the nucleus of the solitary tract; vStriat., ventral striatum; Hypothal, hypothalamus. (B) Reliable subcortical connections, thresholded P < 0.05 uncorrected, replicated in 270 participants.