Table 1.
Brain activation in response to moderately vs mildly painful stimulation
| MNI peak coordinates in mm |
|||||
|---|---|---|---|---|---|
| Brain region | Cluster size (mm3) | z score peak | x | y | z |
| Cluster spanning: | 42938 | 4.71 | −36 | 6 | 10 |
| central opercular cortex, | 4.71 | −36 | 6 | 10 | |
| insula, | 4.59 | −40 | −20 | 12 | |
| SII | 4.57 | −54 | 0 | 8 | |
| Cluster spanning: | 41520 | 4.46 | −4 | 14 | 32 |
| pdACC, | 4.46 | −4 | 14 | 32 | |
| parietal cortex, | 3.95 | 16 | −48 | 64 | |
| SMA | 3.55 | −8 | −2 | 60 | |
| cerebellum | 36816 | 4.01 | −32 | −50 | −50 |
| Cluster spanning: | 30520 | 5.34 | 54 | −14 | 18 |
| SII, | 5.34 | 54 | −14 | 18 | |
| central opercularcortex, | 4.90 | 38 | −16 | 18 | |
| insula | 3.94 | 34 | 14 | 6 | |
Brain areas that were more activated by moderately compared to mildly painful stimulation (significant on a whole brain-level, voxel-based threshold z = 2.3 and cluster-based threshold P < 0.05). Local maxima within the clusters are given for individual anatomical areas. SII, secondary somatosensory cortex; pdACC, posterior-dorsal anterior cingulate cortex; SMA, supplementary motor area.