Table 3.
Surface-based morphometry (SBM) results as a function of Neuroticism scores (n = 507)
| Neuroticism | ||||||||
|---|---|---|---|---|---|---|---|---|
| A. Association between neuroticism and cortical thickness (positive correlations) | ||||||||
| Cortical region | Hemisphere | Max | Size (mm2) | X | Y | Z | CWP | Effect size |
| Supramarginal | L | 4.590 | 6973.54 | −58 | −26.5 | 15.2 | 0.0001 | 0.0176 |
| Superior frontal | L | 4.065 | 13528.12 | −15.3 | 43.2 | 46.3 | 0.0001 | 0.0175 |
| R | 5.713 | 10165.41 | 16.7 | 40.8 | 44.5 | 0.0001 | 0.0181 | |
| Superior parietal | R | 4.639 | 4379.54 | 19.8 | −39.8 | 63.9 | 0.0001 | 0.0176 |
| Postcentral | R | 4.142 | 2082.04 | 46.7 | −16.4 | 57.4 | 0.0030 | 0.0170 |
| Superior temporal | R | 2.833 | 1622.64 | 69.8 | −23.7 | 2.3 | 0.0186 | 0.0161 |
| B. Association between neuroticism and surface area (negative correlations) | ||||||||
| Cortical region | Hemisphere | Max | Size (mm2) | X | Y | Z | CWP | Effect size |
| Middle temporal | L | 4.734 | 6906.27 | −64.8 | −20 | −20.3 | 0.0001 | 0.0186 |
| R | 3.816 | 9699.43 | 66.5 | −12 | −19.5 | 0.0001 | 0.0193 | |
| Rostral middle frontal | L | 2.871 | 2475.52 | −20.4 | 64.9 | 3.6 | 0.0118 | 0.0156 |
| Superior frontal | L | 2.867 | 3049.79 | −23.2 | 15.8 | 54.1 | 0.0025 | 0.0171 |
| R | 4.015 | 2217.56 | 11.4 | 18.5 | 35.1 | 0.0208 | 0.0166 | |
| Cuneus | L | 2.687 | 5598.38 | −2.4 | −83.4 | 13.3 | 0.0001 | 0.0153 |
| Superior parietal | R | 3.110 | 2046.76 | 4.4 | −86.3 | 34.2 | 0.0345 | 0.0166 |
| Frontal pole | R | 3.019 | 5238.06 | 8.1 | 68.9 | −2.2 | 0.0001 | 0.0175 |
| C. Association between neuroticism and cortical volume (negative correlations) | ||||||||
| Cortical region | Hemisphere | Max | Size (mm2) | X | Y | Z | CWP | Effect size |
| Middle temporal | L | 3.221 | 2316.37 | −59.7 | −23.6 | −21.3 | 0.0012 | 0.0176 |
| Superior temporal | L | 2.741 | 1386.99 | −44.1 | 1.8 | −19.2 | 0.0396 | 0.0168 |
| Lateral occipital | L | 2.447 | 2041.32 | −22.9 | −97.8 | 17.4 | 0.0038 | 0.0148 |
| Fusiform | R | 3.844 | 5374.52 | 43.7 | −31.1 | −22.8 | 0.0001 | 0.0173 |
| D. Association between neuroticism and local gyrification index (negative correlations) | ||||||||
| Cortical region | Hemisphere | Max | Size (mm2) | X | Y | Z | CWP | Effect size |
| Middle temporal | L | 4.816 | 30411.64 | −65.3 | −19.9 | −12 | 0.0001 | 0.0172 |
| Caudal middle frontal | L | 4.251 | 15823.58 | −29.5 | 20.4 | 44.6 | 0.0001 | 0.0162 |
| Lateral occipital | R | 5.057 | 7929.12 | 29.5 | −88.4 | 2.9 | 0.0001 | 0.0181 |
| Supramarginal | R | 3.267 | 6820.13 | 46.3 | −35.2 | 23.3 | 0.0001 | 0.0158 |
| Rostral middle frontal | R | 2.884 | 3513.25 | 29.1 | 42.2 | 30.4 | 0.0001 | 0.0157 |
| Posterior cingulate | R | 2.042 | 2544.36 | 8.4 | 3 | 41.9 | 0.0001 | 0.0142 |
| Superior parietal | R | 1.681 | 1022.58 | 32.9 | −49.7 | 49.3 | 0.0063 | 0.0139 |
Associations between neuroticism and cortical thickness (A), surface area (B), cortical volume (C) and local gyrification index (D). X, Y, Z: MNI coordinates of the local maxima; L: Left; R right; CWP: cluster-wise P values; MNI: Montreal Neurological Institute.