Fig. 3. Photo-uncaging of 1 leads to a decrease in inflammatory mediator production by macrophages. Bone marrow derived macrophages (BMDM) from mice were treated with the indicated combinations of lipopolysaccharide (LPS, 100 ng mL^–1), SAHA (500 nM), and/or 1 (3 μM). Cells were then irradiated with UV light (365 nm, 10 min, white bars) or kept in the dark (black bars), and secretion of (A) IL-6 and IL-12 and (B) NO were measured by ELISA and the Griess assay, respectively, after 24 h. **p < 0.01, ***p < 0.001.