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Hemodynamic effects of volume loading before and after pericardial resection. With chest intact, minimally-invasive percutaneous pericardial resection significantly attenuated the increase in left ventricular end diastolic pressure (LVEDP) during rapid saline loading and enhanced the increase in left ventricular end diastolic volume (LVEDV), both in normal dogs (top panels) and in a pig model with features of human HFpEF (bottom panels). Error bars reflect SEM.
