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. Author manuscript; available in PMC: 2017 Apr 13.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Jun 12;18(14):4064–4067. doi: 10.1016/j.bmcl.2008.05.098

Scheme 1. Synthesis of key intermediate 1a.

Scheme 1

Reagents and Conditions. Synthesis of amine 1a: (a) PhLi, THF, -78 °C; (b) H2, 40 psi, Pd/BaSO4, EtOH, 2eq, HCl, 60 °C ; (c) 4a, CbzCl, K2CO3, H2O/THF, 4b, Teoc-Succinimide, Et3N, CH3CN; (d) NaH, DMF; (e) Boc2O, DMAP, Et3N, THF; (f) TFA,CH2Cl2.