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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Stroke. 2017 Mar 14;48(4):1052–1060. doi: 10.1161/STROKEAHA.116.015590

Figure 5. MCP-1-mediated aneurysm healing is IL-6 dependent.

Figure 5

C57BL/6 mice harboring aneurysms implanted with MCP-1-releasing coils were administered an antibody antagonist of IL-6 receptor (anti-IL-6R; 200μg/mL/injection, n=10 each) or IgG control (n=10 each). A) IL-6R blocked aneurysms had significantly reduced tissue ingrowth compared with IgG control. B) Hematoxylin and eosin staining of representative sections of MCP-1-releasing coil implanted aneurysms with anti-IL-6R, IgG control or normal artery. Scale bar = 200μm. C) Temporal sequence of IL-6R blockade revealed that IL-6 has significant role in MCP-1-mediated aneurysm healing between 3 days and 1 week after coil implant. (n=10 each) D) C57BL/6 mice harboring aneurysms implanted with IL-6-releasing coils did not improve intra-aneurysmal tissue healing (n=15 each).