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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Stroke. 2017 Mar 14;48(4):1052–1060. doi: 10.1161/STROKEAHA.116.015590

Figure 6. MCP-1-IL-6-mediated aneurysm healing is OPN dependent.

Figure 6

A) Cytokine array analysis on 3-days, 1-week, 2-week and 3-week murine MCP-1-releasing coil treated with IL-6R blocked aneurysm tissues was performed. IL-6R blockade decreased expression of OPN in MCP-1-releasing coil treated aneurysm (n=5 each). B) MCP-1-coil-treated murine aneurysms from mice administered an antibody antagonist of OPN (100μg/mL/injection) (n=10) had significantly reduced intra-aneurysmal tissue ingrowth compared to the control group (n=10). C) OPN-releasing coil treated aneurysms (n=15) have significantly increased aneurysm healing compared to PLGA-control-coil-implanted aneurysm (n=15) (P=0.001). D) Immunofluorescent staining of human “healed” aneurysms express OPN in the tissue ingrowth of the coiled part of the aneurysm. Scale bar = 50μm.