Table 1.

rs12959006 predicting CDMS, relapse and annualized ΔEDSS in MS among participants with a classic FDE

rs12959006	N	CDMS	N	Relapse	N	ΔEDSS
CC	41	Ref	70	Ref	37	0.26 (0.20, 0.32)
CT + TT	27	1.57 (0.93, 2.64)	82	1.74 (1.19, 2.56)	24	+0.18 (0.06, 0.30)
		p = .09		p  = .005		p  = .004

HR, hazard ratio; CI, confidence interval; β, beta coefficient; EDSS, Expanded Disability Status Scale; FDE, first demyelinating event.

Due to the small number people carrying TT genotype who converted to CDMS (N = 2), we recoded the genotype as CT + TT. Genotype CC was used as reference in the analysis. Results were adjusted for age, sex and study site, and presented as HR (95% CI) for time to CDMS and relapse. Disability results are presented as geometric mean annualized disability progression (95% CI) for the reference group, whereas coefficient relative to reference (β [95% CI]) are presented for subsequent levels. N refers to the number of events for each related clinical course. p value <0.05 bolded.