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Hypercapnia inhibits proliferation of alveolar epithelial cells due to mitochondrial dysfunction resulting from hypercapnia‐induced miR‐183 which down‐regulates the TCA cycle enzyme isocitrate dehydrogenase‐2 (IDH2). Hypercapnic acidosis impairs alveolar epithelial cell migration by the NF‐κB‐dependent mechanism.
