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. 2015 Mar 11;5:9000. doi: 10.1038/srep09000

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(A) Chiral separation of (+)-pioglitazone and (-)-pioglitazone in brain samples of mice administered with racemic pioglitazone; chromatogram in box shows (+)-pioglitazone and (-)-pioglitazone in blank brain sample spiked with racemic pioglitazone.(B) Chiral separation of (+)-pioglitazone and (-)-pioglitazone in plasma samples of mice administered with racemic pioglitazone; chromatogram in box shows (+)-pioglitazone and (-)-pioglitazone in blank plasma sample spiked with racemic pioglitazone.