Fig 4. Bayesian network learned from the information of patients of the subgroups A-C and associated neurologists with the bnlearn R package.

All patient-related factors are colored in green and all physician-related factors are colored in blue. JCV seroconversion during observation period, physicians’ opinion on continuation/discontinuation of NTZ in the individual patient, assessment of PML risk in general, number of treated patients per year and patients’ perception of personal PML risk, duration of NTZ treatment and relapses during the course of the study were directly associated with patients’ discontinuation of NTZ therapy (those factors are pictured as completely colour-filled boxes). For all other examined factors we found no relationship with NTZ treatment cessation (those factors are pictured as white boxes).