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. 2017 Apr 13;12(4):e0175758. doi: 10.1371/journal.pone.0175758

Fig 2. The effect of MET antibody isotypes on pAKT in Caki-1 cells.

Fig 2

(A) The humanized IgG4 MET antibody (LY2875358), hIgG4 and mIgG1 induce weak phosphorylation of pan-AKT as compared to the strong phosphorylation of pan-AKT by agonist antibody 5D5 and HGF [12]. (B) Comparison of IgG1 (purple), IgG2 (blue) and IgG4 MET antibodies (red). (C) The sequences in the hinges. The numbering of the first residue is shown in each sequence. The inter-heavy-chain disulfide bonded cysteine residues are indicated in yellow boxes.