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Substrate specificity determining residues of ACMS modules
| Nonribosomal codons in
| ||
|---|---|---|
| Module | Streptomyces chrysomallus | Streptomyces antibioticus |
| ACMS II | FWNVGMVH (threonine) | FWNVGMVH (threonine) |
| ACMS II | AYFWGVTF (isoleucine) | AYWWGVTF (valine) |
| ACMS III | VQFAAHVV (proline) | VQFAAHVV (proline) |
| ACMS III | ILQLGLIW (glycine) | ILQLGLIW (glycine) |
| ACMS III | AYWWGVTF (valine) | AYWWGVTF (valine) |
Abbreviation: ACMS, actinomycin synthetase.
