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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Nov 5;101:134–144. doi: 10.1016/j.yjmcc.2016.10.016

Figure 4.

Figure 4

a) Overlay of 2D HSQC spectra of cChimera acquired during titration with 3-mDPA. The first point of each titration is represented with multiple contours and subsequent titration points for the drug are represented by single contours. Residues that experienced large chemical shift changes are labeled. b) Global fit for residues in cChimera that experienced large chemical shift perturbations upon addition of 3-mDPA. KD ~ 30 μM.