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. 2017 Apr 4;11:1135–1146. doi: 10.2147/DDDT.S131487

Table S1.

Genotypes associated with atorvastatin pharmacokinetics and lipid-lowering response

Category Gene rs number Nucleotide (AA) change Call rate (%) MAF Major/minor allele Associated variable P-value
Phase I ADH6 rs10002894 c.-931C>T 98.3 0.155 T/C Cmax 0.028
ALDH2 rs671 c.1369G>A (p.Glu504Lys) 100 0.076 G/A CLadj 0.010
ALDH3A1 rs2072330 c.741T>A (p.Pro247=) 96.6 0.342 T/A Cmax 0.015
CBR1 rs1005695 c.397+210G>C 98.3 0.379 G/C %ΔTC 0.011
%ΔLDL-C 0.005
rs998383 c.*559C>G 100 0.356 C/G %ΔTC 0.011
%ΔLDL-C 0.005
CYP1B1 rs1056837 c.1347T>C (p.Asp449=) 100 0.127 C/T %ΔLDL-C 0.048
CYP2B6 rs2279344 c.822+183G>A 100 0.395 A/G CLadj 0.046
CYP2E1 rs3813867 c.-1295G>C 100 0.234 G/C Cmax 0.024
rs2031920 c.-1055C>T 100 0.218 C/T Cmax 0.040
CYP4F2 rs2074900 c.1029C>T (p.His343=) 100 0.169 C/T Cmax 0.024
CYP4F8 rs4239614 c.*52C>T 98.3 0.224 T/C AUC∞ 0.049
Cmax 0.032
CYP4F11 rs3765070 c.318T>C (p.Ile106=) 100 0.424 T/C %ΔLDL-C 0.019
rs1060463 c.1336G>A (p.Asp446Asn) 100 0.407 G/A %ΔLDL-C 0.019
CYP11B1 rs4534 c.128G>A (p.Arg43Gln) 100 0.381 G/A AUC∞ 0.027
Cmax 0.047
CLadj 0.038
CYP11B2 rs4536 c.873G>A (p.Ala291=) 100 0.441 A/G AUC∞ 0.010
CLadj 0.010
CYP19A1 rs700519 c.790C>T (p.Arg264Cys) 100 0.136 C/T %ΔLDL-C 0.031
rs4646 c.*161T>G 100 0.093 G/A AUC∞ 0.010
EPHX1 rs1051740 c.337T>C (p.Tyr113His) 100 0.373 T/C CLadj 0.012
FMO3 rs1736557 c.769G>A (p.Val257Met) 98.3 0.129 G/A Cmax 0.026
rs2266780 c.923A>G (p.Glu308Gly) 100 0.203 A/G CLadj 0.014
%ΔTC 0.031
Phase II CHST10 rs4149521 c.*39T>C 100 0.059 T/C AUC∞ 0.029
Cmax 0.007
%ΔTC 0.007
CHST13 rs3856650 c.97+3926T>A 98.3 0.267 T/A AUC∞ 0.019
Cmax 0.003
CLadj 0.043
rs4305381 c.98-5237A>C 98.3 0.216 A/C Cmax 0.045
%ΔTC 0.034
rs1873397 c.180+2676C>G 100 0.229 G/C Cmax 0.007
GSTA3 rs512795 c.272+161A>G 100 0.339 A/G Cmax 0.045
GSTA4 rs367836 c.*137C>A 98.3 0.172 A/C %ΔTC 0.010
NAT2 rs1799931 c.857G>A (p.Gly286Glu) 100 0.144 G/A %ΔTC 0.030
%ΔLDL-C 0.047
SULT1B1 rs11731028 c.376-2858G>A 100 0.220 G/A %ΔLDL-C 0.037
SULT1C2 rs17036104 c.796T>G (p.Ser266Ala) 96.6 0.105 T/G AUC∞ 0.006
CLadj 0.007
UGT2B4 rs1966151 c.*225T>C 94.9 0.491 T/C AUC∞ 0.027
CLadj 0.040
UGT2B15 rs3100 c.*168C>T 100 0.212 C/T Cmax 0.014
rs4148271 c.*185A>T 98.3 0.181 A/T AUC∞ 0.045
Cmax 0.007
UGT8 rs4148254 c.677C>T (p.Pro226Leu) 100 0.085 C/T AUC∞ 0.018
CLadj 0.031
Transporter ABCB1 rs10276036 c.1000-44G>A 98.4 0.451 G/A AUC∞ 0.040
rs2235033 c.1554+24T>C 100 0.444 T/C AUC∞ 0.028
ABCB11 rs2287622 c.1331T>C (p.Val444Ala) 100 0.271 C/T %ΔLDL-C 0.037
ABCB4 rs2302387 c.175C>T (p.Leu59=) 100 0.220 C/T Cmax 0.029
ABCC1 rs246221 c.825T>C (p.Val275=) 100 0.441 T/C %ΔLDL-C 0.005
rs4148380 c.*1293G>A 100 0.093 G/A %ΔLDL-C 0.043
ABCC2 rs2273697 c.1249G>A (p.Val417Ile) 100 0.113 G/A %ΔTC 0.003
%ΔLDL-C 0.023
ABCG2 rs2231142 c.421C>A (p.Gln141Lys) 100 0.250 C/A CLadj 0.025
SLC5A6 rs1395 c.1442C>T (p.Ser481Phe) 100 0.127 T/C %ΔLDL-C 0.029
SLC7A7 rs2281677 c.-86T>C 100 0.364 C/T AUC∞ 0.029
Cmax 0.021
SLC7A8 rs7141505 c.-1065G>T 98.3 0.155 T/G Cmax 0.034
rs2268877 c.152-1008T>C 98.3 0.371 T/C CLadj 0.038
rs910795 c.508+1988T>C 98.3 0.293 T/C %ΔLDL-C 0.043
SLC10A2 rs7987433 c.-457A>G 100 0.085 A/G %ΔLDL-C 0.045
rs279942 c.*373C>G 100 0.212 C/G %ΔTC 0.041
SLC25A27 rs9381468 c.299-1425A>G 100 0.483 G/A %ΔTC 0.043
SLCO1A2 rs7957203 c.61-5605T>A 100 0.271 T/A AUC∞ 0.039
SLCO1B1 rs4149015 c.-910G>A 100 0.177 G/A Cmax 0.021
rs4149056 c.521T>C (p.Val174Ala) 100 0.177 T/C Cmax 0.023
SLCO1B3 rs4149117 c.334G>T (p.Ala112Ser) 98.4 0.320 G/T Cmax 0.010
rs7311358 c.699G>A (p.Met233Ile) 100 0.306 A/G Cmax 0.010
rs2053098 c.1557A>G (p.Ala519=) 100 0.314 G/A Cmax 0.010
SLCO3A1 rs2283458 c.1513-1102A>G 100 0.398 G/A Cmax 0.025
SLCO4A1 rs2236553 c.797-286C>T 100 0.195 T/C AUC∞ 0.010
CLadj 0.017
SLCO5A1 rs16936279 c.*295A>C 100 0.254 A/C Cmax 0.030
CLadj 0.043
Others AHR rs2066853 c.1661G>A (p.Arg554Lys) 100 0.415 G/A %ΔLDL-C 0.028
ATP7B rs2277448 c.-75C>A 100 0.390 A/C Cmax 0.031
COMT rs4633 c.36C>T (p.His12=) 100 0.254 C/T %ΔTC 0.006
rs4680 c.322G>A (p.Val108Met) 100 0.263 G/A %ΔTC 0.007
NR1I2 rs3814055 c.-1135C>T 98.3 0.302 C/T AUC∞ 0.023
CLadj 0.022
PGAP3 rs2952151 c.*560T>C 100 0.458 T/C AUC∞ 0.010
CLadj 0.012

Abbreviations: AA, amino acid; AUC∞, area under the plasma concentration curve from hour 0 to infinity; CLadj, clearance adjusted with body weight; Cmax, maximum drug concentration in plasma; %ΔLDL-C, percentage change in low-density lipoprotein cholesterol from baseline to 48 hours after atorvastatin administration; MAF, minor allele frequency; %ΔTC, percentage change in total cholesterol from baseline to 48 hours after atorvastatin administration.