Table 2.
Atorvastatin pharmacokinetics in 50 healthy individuals
| Parameter | Mean | SD | CV | Range |
|---|---|---|---|---|
| AUC∞ (ng⋅h/mL) | 172 | 94.9 | 55.3% | 48.9–508.8 |
| Cmax (ng/mL) | 36.2 | 19.3 | 53.3% | 9.5–92.2 |
| tmax (h) | 1.07 | 0.89 | 81.8% | 0.5–4.0 |
| CL (L/h) | 603 | 310 | 51.3% | 157–1,636 |
| CLadj (L/(h⋅kg)) | 8.85 | 4.54 | 51.1% | 2.5–25.2 |
| t1/2 (h) | 7.75 | 2.56 | 33.3% | 2.1–17.0 |
Abbreviations: AUC∞, area under the plasma concentration curve from hour 0 to infinity; CL, clearance; CLadj, clearance adjusted with body weight; Cmax, maximum drug concentration in plasma; CV, coefficient of variation; SD, standard deviation; t1/2, half-life; tmax, time to Cmax.