Fig. 1.

The inter-organ regulation of adipose tissue browning. The schematic illustrates the cellular and molecular mechanisms of inter-organ regulation of adipose tissue browning in mice, human or both. A number of organs, tissues and cells have been found to either act alone or in concert to promote browning of white adipose tissue. This simplified overview delineates the regulation of beige adipocyte induction by central nervous system (CNS), sympathetic nervous system (SNS), immune cells, skeletal muscle, heart, gut, liver, adipose tissue, disease-associated, or tissue non-specific factors (for details, see the text)