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. Author manuscript; available in PMC: 2017 Oct 5.
Published in final edited form as: Nature. 2017 Apr 5;544(7649):185–190. doi: 10.1038/nature21686

Figure 5. Dietary supplementation of MUFAs is sufficient to extend lifespan.

Figure 5

a, Chemical structure of fatty acids used in supplementation experiments. b, GC-MS. Mean ± s.e.m. of 3 independent experiments, each with 2-3 biological replicates. c, Oleic acid supplementation extends lifespan in wild-type worms (P < 0.0001, log-rank). Inset: ORO quantification. Mean ± s.d., n ≥ 27 worms per condition. d, GC-MS. Mean ± s.e.m. of 2 independent experiments, each with 2-3 biological replicates. e, Palmitoleic acid supplementation extends lifespan in wild-type worms (P < 0.0001, log-rank). Inset: as in c, n ≥ 45 worms per condition. f, Mean lifespan changes in independent supplementation experiments (P values: log-rank). g, FAT-7 overexpression extends lifespan (P < 0.0001, log-rank), which is not further extended by dietary oleic acid. P values: Two-tailed Mann-Whitney (Benjamini-Hochberg correction for > 1 comparison). * P < 0.05, ** P < 0.01, *** P < 0.001.