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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Am J Surg Pathol. 2017 May;41(5):655–662. doi: 10.1097/PAS.0000000000000835

Figure 3.

Figure 3

Case 3. This renal cell carcinoma demonstrates nested and papillary architecture and epithelioid cells with clear to eosinophilic cytoplasm (A, B). A subpopulation of smaller cells is present within the lumens of acini. The neoplastic cells are diffusely immunoreactive for cathepsin k (C). While conventional TFE3 FISH did not demonstrate rearrangement, the neoplasm demonstrated diffuse, strong nuclear labeling for TFE3 protein with a clean background (D), prompting additional FISH fusion studies which demonstrated the RBM10-TFE3 gene fusion.