Figure 3.
Cutaneous vasodilation (cutaneous vascular conductance; CVC) in response to increasing doses of exogenous acetylcholine alone (ACh; filled circles), during nitric oxide synthase inhibition (L-NAME; open circles), during inhibition of H2S-producing enzymes (AOAA; open squares), and during combined nitric oxide and H2S inhibition (L-NAME+AOAA; open triangles) in normotensive (NTN; Panels A-C) and hypertensive adults (HTN; Panels D-F). Maximal CVC (max) was elicited by perfusion of sodium nitroprusside during local heating to 43°C at the conclusion of the ACh dose-response protocol. *P<0.05 vs. ACh alone.