TABLE 1. Characteristics of the Study Population.
All values reflect measurements taken when participants were maintained on a liberalized dietary sodium intake, unless otherwise indicated.
| Characteristic | Value |
|---|---|
| Age (years) | 40.4 ± 12.4 |
| Race/Ethnicity (%Caucasian) | 72 |
| Male Sex (%) | 53 |
| Body mass index (kg/m2) | 25.7 ± 4.3 |
| Systolic BP (mmHg) | 113.8 ± 12.6 |
| ARR (ng/dL per ng/mL/h) | 15.4 ± 13.7 11.6 [6.9–25.9] |
| ARR ≥ 20 (ng/dL per ng/mL/h) (n/n; %) | 55/210; 26 |
| Supine Serum Aldosterone (ng/dL) | 3.48 ± 1.8 2.8 [2.5–4.1] |
| Supine PRA (ng/mL/h) | 0.38 ± 0.3 0.30 [0.13–0.49] |
| Supine PRA on RES (ng/mL/h) | 2.88 ± 2.1 2.27 [1.2–4.2] |
| Standing Posture PRA on RES (ng/mL/h) | 9.89 ± 6.9 8.50 [4.7–12.9] |
| Serum potassium (mmol/L) | 4.11 ± 0.3 |
| ΔALDOAngII | 7.45 ± 5.6 (+227%) |
| Renal plasma flow (mL/min/1.73m2) | 558 ± 132 |
| Urinary sodium (mmol/24h) | 248.3 ± 68.1 |
| Urinary potassium (mmol/24h) | 77.4 ± 26.7 |
| Urinary sodium-to-potassium excretion ratio (mmol/mmol per 24h) | 3.55 ± 1.45 |
| Aldosterone excretion rate (mcg/24h) | 8.13 ± 7.1 Range= 1.1–79.9 |
Data are presented as mean +/− SD for continuous variables and frequencies (%) for categorical variables. Non-normally distributed variables are also presented as median with interquartile ranges. Aldosterone excretion rate is presented as mean +/− SD and with the range of the full distribution. BP=blood pressure; ARR=aldosterone-to-renin ratio; PRA=plasma renin activity; ΔALDOAngII=the change in serum aldosterone following an infusion of angiotensin II; RES=dietary sodium restriction.