Table 1.

Specific questions considered during discussions with OP experts

• What effect does decline in physical function have on the daily lives of people with OP?

• What is the value of improvement of physical function and ability to perform daily activities requiring physical function to people with OP?

• What is the value of maintaining physical function and the ability to perform daily activities requiring physical function to people with OP?

• How strong is the relationship between fracture occurrence and ability to perform daily activities requiring physical function in OP? To what extent does this vary between individuals?

• How much of the decline in physical function experienced by people with OP is not explained by fracture occurrence?

• What other factors affect physical function and performance of daily activities requiring physical function in people with OP?

• What are the unmet needs or gaps in current treatment in relation to the effect of OP on peoples’ performance of daily activities requiring physical function?

• What is the added value of evaluating physical function to inform treatment effectiveness? What does measurement of physical function capture that is not already explained by fracture occurrence?