Table 4.
Comparison of genotypes distribution among the patients group with different pharmacokinetic profiles
| Sequence change | Genotype | Poor metabolisers | Intermediate metabolisers | Rapid metabolisers | p-Value | |||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | |||
| CYP2C9 c.1075A>C (p.Ile359Leu) | AA | 18 | 90 | 39 | 93 | 20 | 87 | 0.99 |
| AC | 2 | 10 | 3 | 7 | 3 | 13 | ||
| CC | 0 | 0 | 0 | 0 | 0 | 0 | ||
| CYP2B6 c.516G>T (p.Gln172His) | GG | 16 | 80 | 27 | 64 | 14 | 61 | 0.03* |
| GT | 4 | 20 | 15 | 36 | 6 | 26 | ||
| TT | 0 | 0 | 0 | 0 | 3 | 13 | ||
| UGT1A9 c.98T>C (p.Met33Thr) | TT | 18 | 90 | 40 | 95 | 23 | 100 | 0.35 |
| TC | 2 | 10 | 2 | 5 | 0 | 0 | ||
| CC | 0 | 0 | 0 | 0 | 0 | 0 | ||
*Statistically significant