Table 1. Plasma fibrinogen and serum CA-125 levels, neutrophil to lymphocyte and PLRs according to clinico-pathologic characteristics in 217 patients with advanced-stage EOC.
| Characteristics | No. (%) | Plasma fibrinogen levels (mg/dL) | Serum CA-125 levels (IU/mL) | NLR | PLR | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean±SD | p-value | Mean±SD | p-value | Mean±SD | p-value | Mean±SD | p-value | |||
| Age (yr) | 0.389 | 0.193 | 0.689 | 0.914 | ||||||
| ≤54 | 112 (51.6) | 476.2±145.6 | 2,572.3±4,538.3 | 4.36±2.56 | 292.23±156.93 | |||||
| >54 | 105 (48.4) | 494.7±168.7 | 6,456.6±2,993.9 | 4.57±4.70 | 295.19±237.72 | |||||
| FIGO stage | 0.001 | 0.860 | 0.139 | 0.538 | ||||||
| III | 167 (77.0) | 466.4±155.8 | 4,303.1±2,360.1 | 4.26±3.28 | 289.08±211.99 | |||||
| IV | 50 (23.0) | 548.1±146.2 | 4,905.3±8,454.6 | 5.15±4.99 | 308.96±152.26 | |||||
| Grade | 0.721 | 0.333 | 0.333 | 0.464 | ||||||
| 1–2 | 64 (29.5) | 474.8±165.3 | 2,113.7±4,269.6 | 3.99±1.91 | 267.12±125.98 | |||||
| 3 | 153 (70.5) | 484.4±152.4 | 3,050.5±5,973.7 | 4.66±4.53 | 293.71±231.75 | |||||
| Histology | 0.758 | 0.182 | 0.080 | 0.001 | ||||||
| Serous | 162 (74.7) | 484.8±150.1 | 5,574.5±2,428.1 | 4.72±4.20 | 312.65±217.79 | |||||
| Non-serous | 54 (25.3) | 477.3±166.6 | 1,138.8±2,329.9 | 3.69±1.71 | 234.80±116.42 | |||||
| Debulking surgery | 0.186 | 0.102 | 0.367 | 0.004 | ||||||
| Optimal | 115 (53.0) | 471.9±159.4 | 2,091.4±4,393.7 | 4.25±3.93 | 257.22±145.32 | |||||
| Suboptimal | 102 (47.0) | 500.2±153.9 | 7,070.3±3,016.6 | 4.71±3.53 | 334.75±241.26 | |||||
| Neoadjuvant chemotherapy | 0.002 | 0.854 | 0.798 | 0.385 | ||||||
| No | 170 (78.3) | 468.0±154.3 | 4,582.6±2,353.1 | 4.43±4.12 | 287.45±210.87 | |||||
| Yes | 47 (21.7) | 547.3±153.1 | 3,938.9±7,203.1 | 4.59±1.86 | 316.12±152.23 | |||||
| Response to chemotherapy | 0.002 | 0.948 | 0.125 | 0.371 | ||||||
| Platinum-sensitive | 193 (88.9) | 473.8±155.3 | 4,474.9±2,197.9 | 4.21±3.05 | 289.37±204.46 | |||||
| Platinum-resistant | 24 (11.1) | 576.5±144.0 | 4,170.1±1,101.9 | 6.51±7.02 | 328.15±155.03 | |||||
EOC, epithelial ovarian cancer; FIGO, International Federation of Gynecology and Obstetrics; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio.