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. 2017 Mar 7;28(3):e36. doi: 10.3802/jgo.2017.28.e36

Table 2. Unfavorable factors affecting PFS and OS in 217 patients with advanced-stage EOC.

Factors Univariate Multivariate
HR 95% CI p-value Adjusted HR 95% CI p-value
PFS
Age ≤54 (yr) 0.909 0.670–1.233 0.540 - - -
FIGO stage IV disease 1.476 1.034–2.106 0.032 - - -
Grade 3 disease 0.827 0.564–1.213 0.331 - - -
Non-serous type 1.067 0.747–1.524 0.721 - - -
Suboptimal debulking surgery 1.710 1.260–2.322 0.001 1.675 1.169–2.400 0.005
No neoadjuvant chemotherapy 0.781 0.545–1.119 0.178 - - -
Fibrinogen >485.2 (mg/dL) 1.590 1.172–2.157 0.003 1.389 0.979–1.972 0.066
CA-125 >4,442.5 (U/mL) 1.373 0.936–2.015 0.105 - - -
NLR >4.46 0.910 0.665–1.246 0.557 - - -
PLR >293.66 1.164 0.851–1.592 0.341 - - -
OS
Age ≤54 (yr) 0.813 0.561–1.178 0.274 - - -
FIGO stage IV disease 1.493 0.982–2.270 0.061 - - -
Grade 3 disease 1.586 1.003–2.508 0.048 - - -
Non-serous type 1.387 0.924–2.083 0.115 - - -
Suboptimal debulking surgery 2.105 1.439–3.080 <0.001 2.124 1.374–3.283 0.001
No neoadjuvant chemotherapy 1.009 0.633–1.609 0.968 - - -
Fibrinogen >485.2 (mg/dL) 1.627 1.124–2.354 0.010 1.581 1.032–2.423 0.035
CA-125 >4,442.5 (U/mL) 1.064 0.668–1.696 0.794 - - -
NLR >4.46 1.198 0.824–1.741 0.345 - - -
PLR >293.66 1.544 1.065–2.237 0.022 - - -

EOC, epithelial ovarian cancer; FIGO, International Federation of Gynecology and Obstetrics; NLR, neutrophil to lymphocyte ratio; OS, overall survival; PFS, progression-free survival; PLR, platelet to lymphocyte ratio.