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. 2017 Apr 13;91(9):e01596-16. doi: 10.1128/JVI.01596-16

FIG 6.

FIG 6

Blood HIV-1 antigen-specific T cell responses elicited by anti-LOX-1.Env gp140 and anti-CD40.Env gp140 fusion protein administration. PBMCs were analyzed by IFN-γ ELISPOT assay for responses to three Env gp140 peptide pools. Sample collection times are shown in weeks below the graph. Dots are results for individual animals, and the box plots represent the distribution of values, with the bars indicating the median values for the group. No significant responses were detected against non-Env HIV peptides (data not shown). Statistical analysis of blood HIV-1 antigen-specific T cell responses elicited at week 26 by anti-LOX-1.Env gp140 and anti-CD40.Env gp140 fusion protein administration, according to IFN-γ ELISPOT assay, summed over all antigens by the Wilcoxon rank sum test comparing G1 versus G3 (P = 0.699), G2 versus G4 (P = 0.065), G1 versus G2 (P = 0.180), G3 versus G4 (P = 0.818), and G4 versus G5 (P = 0.143). For the week 32 data, the analysis compared G1 versus G3 (P = 0.699), G2 versus G4 (P = 0.009), G1 versus G2 (P = 0.015), G3 versus G4 (P = 1.000), and G4 versus G5 (P = 0.010).