FIG 8.

Specificity and magnitude of blood HIV-1 antigen-specific CD8⁺ T cell responses elicited by anti-LOX-1.Env gp140 and anti-CD40.Env gp140 fusion protein administration. PBMCs from blood collected at weeks 26 and 32 were analyzed by ICS for CD8⁺ T cell responses to HIV-1 antigen peptide pools (indicated above the graph). In contrast to Fig. 6, these data combine IFN-γ, IL-2, and TNF-α cytokine secretion responses as well as integrating responses across all Env proteins (the response patterns represented with combined cytokine responses were similar to those seen when the individual cytokine responses were plotted). Responders are shown in blue and nonresponders in red. Dots are results for individual animals, and the box plots represent the distribution of values, with the bars indicating the median values for the responders in the group (indicated below each panel).