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. Author manuscript; available in PMC: 2017 Apr 14.

Published in final edited form as: Antiviral Res. 2015 Jun 22;121:69–81. doi: 10.1016/j.antiviral.2015.06.014

Therapeutics in development for the management of chronic HBV infection. (A) Investigational agents in Phase 1 clinical trials at the time of writing this review. The NCT number (wherever applicable) after the company's name is the clinicaltrials.gov identifier. (B) Investigational agents in preclinical stages. The stage of development is indicated, from in vitro identification through animal efficacy and ultimately human clinical trials. DAAs are highlighted in green and HTAs in blue. Investigational agents that have failed or have been stopped are shown in red. See text for citations. When we were unable to find a published reference, we cite the sponsor's website.

Therapeutics in development for the management of chronic HBV infection. (A) Investigational agents in Phase 1 clinical trials at the time of writing this review. The NCT number (wherever applicable) after the company's name is the clinicaltrials.gov identifier. (B) Investigational agents in preclinical stages. The stage of development is indicated, from in vitro identification through animal efficacy and ultimately human clinical trials. DAAs are highlighted in green and HTAs in blue. Investigational agents that have failed or have been stopped are shown in red. See text for citations. When we were unable to find a published reference, we cite the sponsor's website.