Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 14;15:77. doi: 10.1186/s12967-017-1179-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — Proposed synthesis of endomorphin-1 by the vitamin C-dependent enzyme peptidylglycine α-amidating monooxygenase (PAM). The enzyme comprises a peptidylglycine α-hydroxylating monooxygenase (PHM) domain, which converts glycine-extended peptides into a hydroxyglycine intermediate, and a peptidyl α-hydroxyglycine α-amidating lyase (PAL) domain, which converts the hydroxyglycine intermediate into an amidated product. AA ascorbic acid, DHA dehydroascorbic acid