Table 7.

Canonical pathways in ingenuity pathway analysis associated with differentially methylated genes between smokers vs. non-smokers and COPD vs. non-smokers

Smokers vs. non-smokers
Canonical pathways	P value	Overlap
B cell development	1.25E-02	3.0% 1/33
Antigen presentation pathway	1.40E-02	2.7% 1/37
Autoimmune thyroid disease signaling	1.77E-02	2.1% 1/47
Graft-vs.-host disease signaling	1.81E-02	2.1% 1/48
Nur77 signaling in T lymphocytes	2.15E-02	1.8% 1/57
COPD vs. non-smokers
Canonical pathways	P value	Overlap
G Beta gamma signaling	5.35E-06	8.1% 7/86
GNRH signaling	6.42E-06	6.5% 8/124
Molecular mechanisms of cancer	6.98E-06	3.6% 13/366
Role of NFAT in cardiac hypertrophy	1.82E-05	4.8% 9/187
nNOS signaling in neurons	2.74E-05	11.1% 5/45