Table 1.
Cellular processes influencing glutathione homeostasis identified by glutathione overexcretion mutants
| Functional group/cellular process | No. of genes | Glutathionea excretion | Examples of mutants |
|---|---|---|---|
| Mitochondrial electron transport chain | 66 | 2-25 | mrs1, cox6, qcr7 |
| RAS/PKA; carbon signaling | 2 | 22-25 | ira2, pde2 |
| Nitrogen signaling amino acid metabolism | 5 | 3-24 | ure2, npr2, gdh1 |
| Secretory pathway; vacuolar protein sorting | 66 | 2-37 | vps2, pep3, pep12 |
| Translation | 10 | 2-11 | tif2, egd1, rpl21a |
| Ubiquitin/proteasome related | 10 | 2-35 | ubp6, ump1, doa1 |
| Cell integrity; cytoskeleton; inositol metabolism | 16 | 2-21 | mpk1, ino1, ecm25 |
| Ion homeostasis | 13 | 2-11 | ptk2, nhx1, vma2 |
| Transcription; chromatin remodeling | 16 | 2-11 | gcn5, snf5, paf1 |
| Miscellaneous | 20 | 2-24 | kcs1, akr1, slx8 |
| Genes of unknown function | 46 | 2-13 | prm7, yim2 |
a
Fold glutathione excreted relative to the parental strain in stationary phase