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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Virology. 2017 Mar 3;505:155–161. doi: 10.1016/j.virol.2017.02.020

Figure 2.

Figure 2

RNA secondary structure of the ε signal. It covers the 3′ 2/3rds of the precore region and the first 7 nucleotides of the core gene, and contains two base-paired regions (stems), a bulge, and a loop. Translation initiation sites for the uORF and core gene are indicated, as is the site of the 36-nt insertion found in genotype G. Most HBV genotypes have T1858, and the G1896A nonsense mutation would improve a base pair from U:G to U:A. Genotypes A, C1, F2, and F3 have C1858 to preclude the rise of the G1896A mutation.