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. 2016 Oct 14;5(12):e1242543. doi: 10.1080/2162402X.2016.1242543

Table 1.

Significantly lower proliferation and significantly higher senescence rates in PC cancer cells compared with pCRC.

  PC (Rate/HPF)
 pCRC (Rate/HPF)
  
Cell Division Rate Mean ± SD 95% CI n Mean ± SD 95% CI n p
Proliferation              
 Ki-67 0.16 ± 0.10 0.12–0.19 35 0.30 ± 0.15 0.24–0.37 23 0.0006
 PCNA 0.17 ± 0.10 0.14–0.21 39 0.48 ± 0.13 0.43 ± 0.52 39 <0.0001
 Cyclin D1 0.10 ± 0.04 0.09–0.12 39 0.20 ± 0.07 0.18–0.22 41 <0.0001
Senescence              
 H3K9me3 0.39 ± 0.18 0.33–0.45 37 0.05 ± 0.09 0–0.11 10 <0.0001
 p21Cip1 0.23 ± 0.09 0.20–0.26 39 0.16 ± 0.12 0.12–0.20 42 0.0005
 CDKN2A 0.60 ± 0.12 0.56–0.64 40 0.22 ± 0.12 0.18–0.26 42 <0.0001

Abbreviations: PC, peritoneal carcinomatosis; pCRC, primary colorectal cancer; Rate, ratio of positive stained cancer cells divided by all cancer cells; HPF, high-power field; SD, standard deviation; CI, confidence interval; Ki67, PCNA and cyclin D1 as proliferation markers; H3K9me3, p21Cip1 and CDKN2A as senescence markers.