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Schematic diagrams for PakB and mutants used in this study. PakB (GenBank accession no. AAC71063) is comprised of a proline-rich N-terminal domain, a PBD, a linker region in which almost one-half the residues are glutamines or asparagines, and a Ser/Thr kinase catalytic domain. The structures of the endogenously generated C-terminal truncation products (PakB-ΔC and PakB-ΔCL) are predicted based on the size of the proteins as determined by SDS-PAGE.
