Table 1.
List of 100 genes most highly enriched in PRV-infected mouse CNS
| Description | Gene ID | Fold increase (infected/control; log2) | q value | Immune response (71)a | Response to interferon (32)b | Defense response to virus/viral process (40)c | Apoptosis (30)d | Protein ubiquitination (10)e | Upregulated in PRV-infected rat CNS (23)f | Upregulated in virulent rabies (91)g | Upregulated in attenuated rabies (87)h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chemokine (C-C motif) ligand 2 | Ccl2 | 8.15 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 2 | Interferon regulatory factor 7 | Irf7 | 7.98 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 3 | Ubiquitin specific peptidase 18 | Usp18 | 7.84 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 4 | Interferon-induced protein with tetratricopeptide repeats 1 | Ifit1 | 7.66 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 5 | Chemokine (C-C motif) ligand 12 | Ccl12 | 7.50 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 6 | ISG15 ubiquitin-like modifier | Isg15 | 7.17 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 7 | Chemokine (C-C motif) ligand 7 | Ccl7 | 6.93 | 0.00073 | ✓ | ✓ | ||||||
| 8 | 2'-5' oligoadenylate synthetase-like 2 | Oasl2 | 6.82 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 9 | Interferon gamma inducible protein 47 | Ifi47 | 6.82 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 10 | Interferon-induced protein with tetratricopeptide repeats 3 | Ifit3 | 6.60 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 11 | Interferon, alpha-inducible protein 27 like 2A | Ifi27l2a | 6.55 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 12 | 2'-5' oligoadenylate synthetase 1A | Oas1a | 6.47 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 13 | Guanylate binding protein 2 | Gbp2 | 6.41 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 14 | Chemokine (C-C motif) ligand 5 | Ccl5 | 6.34 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 15 | Bone marrow stromal cell antigen 2 | Bst2 | 6.34 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 16 | RIKEN cDNA I830012O16 gene | I830012O16Rik | 6.26 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 17 | Receptor transporter protein 4 | Rtp4 | 6.11 | 0.00073 | ✓ | ✓ | ||||||
| 18 | Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | Lilrb4 | 6.00 | 0.00073 | ✓ | |||||||
| 19 | Guanylate binding protein 3 | Gbp3 | 5.99 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 20 | Membrane-spanning 4-domains, subfamily A, member 6D | Ms4a6d | 5.98 | 0.00073 | ✓ | ✓ | ||||||
| 21 | T-cell specific GTPase 2 | Tgtp2 | 5.92 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 22 | Myxovirus (influenza virus) resistance 2 | Mx2 | 5.80 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 23 | Guanylate binding protein 7 | Gbp7 | 5.63 | 0.00073 | ✓ | ✓ | ||||||
| 24 | Sterile alpha motif domain containing 9-like | Samd9l | 5.35 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 25 | Interferon-induced protein with tetratricopeptide repeats 2 | Ifit2 | 5.32 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 26 | Membrane-spanning 4-domains, subfamily A, member 6C | Ms4a6c | 5.26 | 0.00073 | ✓ | ✓ | ||||||
| 27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | Ddx58 | 5.13 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 28 | Schlafen 2 | Slfn2 | 5.12 | 0.00073 | ✓ | ✓ | ||||||
| 29 | Immunity-related GTPase family M member 1 | Irgm1 | 5.09 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 30 | Interferon gamma induced GTPase | Igtp | 5.03 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 31 | Hect domain and RLD 6 | Herc6 | 5.01 | 0.00073 | ✓ | ✓ | ||||||
| 32 | Tripartite motif-containing 30D | Trim30d | 4.99 | 0.00073 | ✓ | |||||||
| 33 | Membrane-spanning 4-domains, subfamily A, member 6B | Ms4a6b | 4.95 | 0.00073 | ✓ | ✓ | ||||||
| 34 | Proteasome subunit, beta type 8 | Psmb8 | 4.91 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 35 | Lipocalin 2 | Lcn2 | 4.91 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 36 | Interleukin 2 receptor, gamma chain | Il2rg | 4.83 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 37 | Activating transcription factor 3 | Atf3 | 4.73 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 38 | Interferon induced transmembrane protein 3 | Ifitm3 | 4.60 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 39 | Interferon regulatory factor 9 | Irf9 | 4.60 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 40 | Nuclear antigen Sp100 | Sp100 | 4.60 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 41 | CD274 antigen | Cd274 | 4.59 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 42 | Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | Tap1 | 4.58 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 43 | Poly (ADP-ribose) polymerase family, member 10 | Parp10 | 4.55 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 44 | Interferon-stimulated protein | Isg20 | 4.45 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 45 | Proteasome subunit, beta type 9 | Psmb9 | 4.42 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 46 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Eif2ak2 | 4.41 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 47 | Signal transducer and activator of transcription 1 | Stat1 | 4.40 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 48 | Poly (ADP-ribose) polymerase family, member 9 | Parp9 | 4.40 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 49 | Immunity-related GTPase family M member 2 | Irgm2 | 4.37 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 50 | Interferon-induced protein 35 | Ifi35 | 4.36 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 51 | Lectin, galactose binding, soluble 9 | Lgals9 | 4.35 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 52 | Expressed sequence AW112010 | AW112010 | 4.33 | 0.00073 | ✓ | ✓ | ||||||
| 53 | Interleukin 18 binding protein | Il18bp | 4.32 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 54 | CD72 antigen | Cd72 | 4.30 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 55 | G protein-coupled receptor 84 | Gpr84 | 4.28 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 56 | Heat shock protein 1 | Hspb1 | 4.19 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 57 | Fc receptor, IgG, high affinity I | Fcgr1 | 4.16 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 58 | Cyclin-dependent kinase inhibitor 1A (P21) | Cdkn1a | 4.15 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 59 | Deltex 3-like (Drosophila) | Dtx3l | 4.15 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 60 | Plasminogen activator, urokinase receptor | Plaur | 4.14 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 61 | Lectin, galactoside-binding, soluble, 3 binding protein | Lgals3bp | 4.12 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 62 | Histocompatibility 2, K1, K region | H2-K1 | 4.11 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 63 | Histocompatibility 2, T region locus 23 | H2-T23 | 4.11 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 64 | Tripartite motif-containing 34A | Trim34a | 3.97 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 65 | CD52 antigen | Cd52 | 3.96 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 66 | Ubiquitin-like modifier activating enzyme 7 | Uba7 | 3.95 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 67 | Torsin family 3, member A | Tor3a | 3.94 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 68 | Poly (ADP-ribose) polymerase family, member 12 | Parp12 | 3.89 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 69 | Beta-2 microglobulin | B2m | 3.89 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 70 | cDNA sequence AB124611 | AB124611 | 3.88 | 0.00073 | ✓ | ✓ | ||||||
| 71 | Complement component 5a receptor 1 | C5ar1 | 3.88 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 72 | Sp110 nuclear body protein | Sp110 | 3.86 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 73 | Lectin, galactose binding, soluble 3 | Lgals3 | 3.86 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 74 | Lymphocyte antigen 6 complex, locus A | Ly6a | 3.85 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 75 | Eukaryotic translation elongation factor 1 alpha 1 pseudogene | Gm6548 | 3.83 | 0.00073 | ✓ | ✓ | ||||||
| 76 | XIAP associated factor 1 | Xaf1 | 3.75 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| 77 | Fc receptor, IgG, low affinity IIb | Fcgr2b | 3.73 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 78 | Complement component 4B (Childo blood group) | C4b | 3.71 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 79 | Ubiquitin-conjugating enzyme E2L 6 | Ube2l6 | 3.71 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 80 | Interleukin 1 alpha | Il1a | 3.62 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 81 | Chemokine (C-C motif) receptor-like 2 | Ccrl2 | 3.61 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 82 | Translocator protein | Tspo | 3.61 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 83 | Chemokine (C-X-C motif) ligand 16 | Cxcl16 | 3.60 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 84 | Cytotoxic T lymphocyte-associated protein 2 alpha | Ctla2a | 3.58 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 85 | Zinc finger protein 36 | Zfp36 | 3.57 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 86 | Tripartite motif-containing 12A | Trim12a | 3.55 | 0.00073 | ✓ | |||||||
| 87 | Complement component 3a receptor 1 | C3ar1 | 3.53 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ||||
| 88 | Capping protein (actin filament), gelsolin-like | Capg | 3.46 | 0.00073 | ✓ | ✓ | ||||||
| 89 | Interferon regulatory factor 1 | Irf1 | 3.45 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 90 | RAB20, member RAS oncogene family | Rab20 | 3.45 | 0.00355 | ✓ | |||||||
| 91 | Growth arrest and DNA-damage-inducible 45 beta | Gadd45b | 3.41 | 0.00073 | ✓ | ✓ | ||||||
| 92 | Early growth response 2 | Egr2 | 3.41 | 0.00073 | ✓ | |||||||
| 93 | Epithelial stromal interaction 1 (breast) | Epsti1 | 3.39 | 0.00073 | ✓ | ✓ | ||||||
| 94 | Intercellular adhesion molecule 1 | Icam1 | 3.39 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 95 | C-type lectin domain family 4, member a3 | Clec4a3 | 3.37 | 0.00073 | ✓ | |||||||
| 96 | Cathepsin C | Ctsc | 3.36 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 97 | B-cell leukemia/lymphoma 2 related protein A1b | Bcl2a1b | 3.33 | 0.00073 | ✓ | |||||||
| 98 | Heme oxygenase (decycling) 1 | Hmox1 | 3.33 | 0.00073 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 99 | Immunoglobulin superfamily, member 6 | Igsf6 | 3.31 | 0.00073 | ✓ | ✓ | ✓ | |||||
| 100 | Histocompatibility 2, D region locus 1 | H2-D1 | 3.29 | 0.00073 | ✓ | ✓ | ✓ |
aImmune response (GO:0002376, GO:0006955).
bResponse to interferon (GO:0060337, GO:0034341, GO:0035456, and GO:0035455).
cDefense response to virus/viral process (GO:0009615, GO:0016032).
dApoptosis (GO:0010942, GO:0043068, GO:0043065).
eProtein ubiquitination (GO:0016567).
fUpregulated in PRV-infected rats CNS (Paulus et al., 2006).
gUpregulated in virulent rabies (strain CVS-11)-infected mice (Zhang et al., 2016).
hUpregulated in attenuated rabies (strain HEP-Flury)-infected mice (Zhang et al., 2016).