Table 2.
Sixty genes with greatest enrichment in afferents to the mesolimbic dopamine circuit (q values <0.005)
| Gene | Description | IP/input | q value | Infected/not infected | IP/input weighted for PRV | |
|---|---|---|---|---|---|---|
| 1 | Slc6a4 | Serotonin transporter/SERT/5-HTT | 9.37 | 0.00067 | 0.74 | 12.73 |
| 2 | Rn45s | 45S preribosomal RNA | 11.76 | 0.00067 | 0.95 | 12.36 |
| 3 | Gchfr | GTP cyclohydrolase I feedback regulator | 4.86 | 0.00067 | 0.47 | 10.34 |
| 4 | Pmch | Pro-melanin-concentrating hormone | 5.02 | 0.00067 | 0.49 | 10.21 |
| 5 | Parpbp | PARP1 binding protein/C12orf48 | 4.96 | 0.00067 | 0.55 | 9.02 |
| 6 | Panx1 | Pannexin 1 | 3.61 | 0.00067 | 0.54 | 6.64 |
| 7 | Cartpt | CART prepropeptide | 3.56 | 0.00067 | 0.58 | 6.19 |
| 8 | Tbca | Tubulin cofactor A | 2.53 | 0.00067 | 0.43 | 5.89 |
| 9 | Gm1673 | predicted gene 1673 | 3.96 | 0.00067 | 0.68 | 5.81 |
| 10 | Eid2 | EP300 interacting inhibitor of differentiation 2 | 4.23 | 0.00125 | 0.75 | 5.68 |
| 11 | Fbll1 | Fibrillarin-like 1 | 3.56 | 0.00067 | 0.64 | 5.55 |
| 12 | Lsm4 | LSM4 homolog, U6 small nuclear RNA associated | 3.12 | 0.00067 | 0.58 | 5.41 |
| 13 | Ydjc | YdjC homolog (bacterial) | 3.39 | 0.00067 | 0.63 | 5.35 |
| 14 | C1qtnf4 | C1q and tumor necrosis factor related protein 4 | 3.67 | 0.00067 | 0.69 | 5.33 |
| 15 | Arhgdig | Rho GDP dissociation inhibitor (GDI) gamma | 3.45 | 0.00067 | 0.66 | 5.24 |
| 16 | Pafah1b3 | Platelet-activating factor acetylhydrolase 1b, subunit | 3.26 | 0.00067 | 0.63 | 5.16 |
| 17 | Ly6 h | Lymphocyte antigen 6 complex, locus H | 4.45 | 0.00067 | 0.86 | 5.15 |
| 18 | Pcbd1 | Pterin 4 alpha carbinolamine dehydratase (TCF1) 1 | 3.34 | 0.00067 | 0.66 | 5.07 |
| 19 | Slc18a3 | Vesicular acetylcholine transporter/VAchT | 3.97 | 0.00180 | 0.78 | 5.07 |
| 20 | Ncrna00086 | Non-protein coding RNA 86 | 2.69 | 0.00067 | 0.55 | 4.88 |
| 21 | Fxyd7 | FXYD domain-containing ion transport regulator 7 | 2.79 | 0.00067 | 0.57 | 4.87 |
| 22 | Vat1 | Vesicle amine transport protein 1 homolog | 3.86 | 0.00125 | 0.81 | 4.79 |
| 23 | 1700037H04 | RIKEN cDNA 1700037H04 gene | 3.16 | 0.00067 | 0.67 | 4.71 |
| 24 | Oxt | Oxytocin | 2.81 | 0.00067 | 0.61 | 4.57 |
| 25 | Th | Tyrosine hydroxylase | 2.89 | 0.00067 | 0.63 | 4.55 |
| 26 | Ndn | necdin | 3.11 | 0.00067 | 0.70 | 4.47 |
| 27 | 2700094K13 | RIKEN cDNA 2700094K13 gene | 3.13 | 0.00067 | 0.71 | 4.44 |
| 28 | Grcc10 | Gene rich cluster, C10 gene | 3.69 | 0.00067 | 0.84 | 4.42 |
| 29 | Nxph4 | Neurexophilin 4 | 5.00 | 0.00067 | 1.13 | 4.41 |
| 30 | Ptov1 | Prostate tumor over expressed 1 | 3.11 | 0.00067 | 0.71 | 4.40 |
| 31 | Lin7b | Lin-7 homolog B (C. elegans) | 2.21 | 0.00067 | 0.51 | 4.35 |
| 32 | Aldh3b2 | Aldehyde dehydrogenase 3 family, member B2 | 2.51 | 0.00067 | 0.59 | 4.25 |
| 33 | Bex1 | Brain expressed gene 1 | 3.49 | 0.00067 | 0.83 | 4.19 |
| 34 | Ctxn2 | Cortexin 2 | 2.91 | 0.00067 | 0.69 | 4.19 |
| 35 | Sncg | Synuclein, gamma | 2.38 | 0.00067 | 0.57 | 4.16 |
| 36 | Slc10a4 | Solute carrier family 10 member 4 | 3.36 | 0.00067 | 0.81 | 4.14 |
| 37 | Bex4 | Brain expressed X-linked 4 | 3.13 | 0.00067 | 0.76 | 4.11 |
| 38 | Rpl22l1 | Ribosomal protein L22 like 1 | 3.59 | 0.00067 | 0.87 | 4.11 |
| 39 | Slirp | SRA step-loop interacting RNA binding protein | 3.97 | 0.00067 | 0.97 | 4.09 |
| 40 | Igsf8 | Immunoglobulin superfamily, member 8 | 3.73 | 0.00067 | 0.92 | 4.06 |
| 41 | 1700001L19 | RIKEN cDNA 1700001L19 gene | 2.01 | 0.00067 | 0.49 | 4.06 |
| 42 | Ttc9b | Tetratricopeptide repeat domain 9B | 4.15 | 0.00067 | 1.04 | 3.99 |
| 43 | Sssca1 | Sjogren's/scleroderma autoantigen 1 homolog | 2.59 | 0.00067 | 0.65 | 3.97 |
| 44 | BC017158 | cDNA sequence BC017158 | 2.62 | 0.00067 | 0.67 | 3.94 |
| 45 | Bahcc1 | BAH domain and coiled-coil containing 1 | 4.09 | 0.00067 | 1.05 | 3.91 |
| 46 | Nrsn2 | Neurensin 2 | 3.26 | 0.00067 | 0.84 | 3.90 |
| 47 | Rhov | Ras homolog gene family, member V | 2.97 | 0.00067 | 0.77 | 3.87 |
| 48 | Tph2 | Tryptophan hydroxylase 2 | 3.13 | 0.00067 | 0.81 | 3.87 |
| 49 | Ecel1 | Endothelin converting enzyme-like 1 | 3.34 | 0.00067 | 0.87 | 3.86 |
| 50 | Abhd8 | Abhydrolase domain containing 8 | 3.46 | 0.00067 | 0.90 | 3.85 |
| 51 | Gm12191 | Predicted gene 12191 | 3.60 | 0.00067 | 0.94 | 3.84 |
| 52 | Gal | galanin | 4.16 | 0.00067 | 1.08 | 3.84 |
| 53 | Psd | Pleckstrin and Sec7 domain containing | 2.80 | 0.00067 | 0.73 | 3.83 |
| 54 | Lrfn3 | Leucine rich repeat and fibronectin type III | 3.00 | 0.00373 | 0.78 | 3.82 |
| 55 | Hcfc1r1 | Host cell factor C1 regulator 1 (XPO1-dependent) | 2.62 | 0.00067 | 0.68 | 3.82 |
| 56 | Sod1 | Superoxide dismutase 1, soluble | 3.04 | 0.00067 | 0.81 | 3.77 |
| 57 | Rps25 | Ribosomal protein S25 | 3.35 | 0.00067 | 0.89 | 3.77 |
| 58 | Resp18 | Regulated endocrine-specific protein 18 | 2.96 | 0.00067 | 0.79 | 3.76 |
| 59 | Sema4f | Sema domain, immunoglobulin domain (Ig) | 2.99 | 0.00067 | 0.79 | 3.76 |
| 60 | Rnf187 | Ring finger protein 187 | 2.82 | 0.00067 | 0.75 | 3.75 |